The State-owned Bethel Airport is the regional transportation center, and is served by two major passenger airlines, two cargo carriers, and numerous air taxi services.

The airport ranks third in the state for total number of flights. It offers a 6,398′ asphalt runway and 1,850′ gravel crosswind runway, and is currently undergoing a $7 million renovation and expansion.

Two float plane bases are nearby, Hangar Lake and H Marker Lake. The Port of Bethel is the northern-most medium-draft port in the U.S. River travel is the primary means of local transportation in the summer, and it becomes a 150-mile ice road to surrounding villages in the winter.

A barge service based in Bethel provides goods to the Kuskokwim villages. There are 16 miles of local roads. Winter trails are marked to Napakiak (1.1 mi.) and Akiachak (19 mi.)